The pharnmacokinetic and pharmacodynamic interactions between high dose catechin-contained green tea and simvastatin

The pharnmacokinetic and pharmacodynamic interactions between high dose catechin-contained green tea and simvastatin - Drug interactions between catechin and simvastatin

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002751

Enrollment

Registered

2009-11-13

Start date

2009-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy man

Interventions

Subjects consume 700ml of catechin-contained green tea(0.65mg/ml) every day for 14 days, and take simvastatin(10mg) on day 14. After 14 days wash-out periods, the subjects consume 700ml of bottle wate

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: healthy man

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
simvastatin pharmacokinetics plasma lathosterol concentration	—

Countries

Japan

Contacts

Public ContactKazuhiko Takeuchi

Hamamatsu University School of Medicine Clinical Pharmacology and Therapeutics

takeutik@hama-med.ac.jp053-435-2385

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026