Detection of markers for immune pathophysiology and analysis of their prognostic value in patients with chronic thrombocytopenia without an increase in the number of bone marrow megakaryocytes: a prospective observation study.

Detection of markers for immune pathophysiology and analysis of their prognostic value in patients with chronic thrombocytopenia without an increase in the number of bone marrow megakaryocytes: a prospective observation study. - Detection of markers for immune pathophysiology and analysis of their prognostic value in patients with chronic thrombocytopenia without an increase in the number of bone marrow megakaryocytes.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000002729

Enrollment

Registered

2009-11-16

Start date

2009-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancytopenia, thrombocytopenia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: No increment of the number of bone marrow megakaryocytes and peripheral blood examination meets the condition as follows; WBC >= 3000 /mcl Hb >= 10 g/dl Platelets < 10 x10e4/mcl

Exclusion criteria

Exclusion criteria: 1) Patients treated by immunosuppressive therapy. 2) Patients with a history of hematologic malignancy. 3) Patients with malignancies requiring treatment.

Design outcomes

Primary

Measure	Time frame
Survival of the 'TDM' patients, maintaining the number of platelets greater than 5.0x10e4/mcl.	—

Secondary

Measure	Time frame
1) Changes of the severity of the diseases graded by the clinical stratification for aplastic anemia. 2) Frequency of patients, positive for PNH-type cells. 3) The choice of treatment selected by attending physician.	—

Countries

Japan

Contacts

Public ContactKen Ishiyama

Kanazawa University Graduate School of Medical Science. Cellular Transplantation Biology

ishiyamak@med3.m.kanazawa-u.ac.jp81-76-265-2274

Outcome results