The influence of glucose administration during surgery on the postoperative glucose metabolism in the patients undergoing elective gastrectomy

The influence of glucose administration during surgery on the postoperative glucose metabolism in the patients undergoing elective gastrectomy - The influence of glucose administration during surgery on the postoperative glucose metabolism

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002710

Enrollment

Registered

2009-12-01

Start date

2009-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant tumor of stomach

Interventions

An extracellular fluid replacement solution containing 1% glucose is administered during surgery. An extracellular fluid replacement solution without glucose is administered during surgery.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients aged 20 years or older 2. Male patients or female patients 3. Patients in ASA category I to II 4. Patients who provide informed consent before registration

Exclusion criteria

Exclusion criteria: 1. Patients with hypermagnesemia 2. Patients with hypothyroidism 3. Diabetic patients, patients with abnormal glucose tolerance, and the patients with such disease histories 4. Patients with severe heart diseases 5. Patients with severe kidney dysfunction 6. Patients with severe liver dysfunction 7. Others who are deemed unsuitable for inclusion in the study for any other reason based on the assessment by the investigator

Design outcomes

Primary

Measure	Time frame
Postoperative glucose metabolism evaluated by the insulin resistance (HOMA-IR) calculated by the following equation: HOMA-IR= serum glucose level (mg/dL) x serum insulin level (microU/mL )/405 The values are measured in early morning of the day following the surgery.	—

Secondary

Measure	Time frame
1. Intraoperative glucose tolerance (serum glucose, insulin, and C-peptide) 2. Intraoperative protein metabolism (urinary 3-methyhistidine) 3. Intraoperative fat metabolism (serum free fatty acid and ketone bodies) The values are measured every 2 hours during the surgery.	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026