Evaluation of effects of enteral nutrient enriched with eicosapentaenoic acid (EPA), gamma-linolenic acid (GLA), and antioxidants in patients underwent radical surgery for thoracic esophageal cancer.

Evaluation of effects of enteral nutrient enriched with eicosapentaenoic acid (EPA), gamma-linolenic acid (GLA), and antioxidants in patients underwent radical surgery for thoracic esophageal cancer. - Evaluation of effects of enteral nutrient enriched with eicosapentaenoic acid (EPA), gamma-linolenic acid (GLA), and antioxidants in patients underwent radical surgery for thoracic esophageal cancer.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002659

Enrollment

Registered

2009-11-01

Start date

2009-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal cancer

Interventions

Enteral formula enriched with EPA, GLA, and antioxidants (experimental diet)(PODs 2-8) Isonitrogenous, isocaloric standard enteral formula (control diet)(PODs 2-8)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients underwent radical surgery for thoracic esophageal cancer along with 2 or 3-field lymphadenectomy patients assessed to be able to consume enteral feeding from 2PODs by attending physician

Exclusion criteria

Exclusion criteria: Palliative and Emergency esophagectomy case Patients with severe immunosuppression Patients with cardiac, liver, or renal failure Patients with abnormal amino acid metabolism Known allergy of milk protein and lactose intolerance Patients assessed to be unsuitable for inclusion the study or enteral feeding

Design outcomes

Primary

Measure	Time frame
improvement in oxygenation condition(PaO2/ FiO2 ratio)	—

Secondary

Measure	Time frame
acute inflammatory reaction transition of maximum body temperature body composition analysis perioperative complication length of post operative hospitalization	—

Countries

Japan

Contacts

Public ContactYasunori Matsuda

Osaka City University Graduate School of medicine Department of Gastroenterological Surgery

m1293311@msic.med.osaka-cu.ac.jp06-6645-3841

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026