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Synergy Effect of the Combination Therapy of Etidronate and Atorvastatin on Atherosclerotic Abdominal Aortic Plaques Detected by Magnetic Resonance Imaging - Open Label Randomized Trial-

Synergy Effect of the Combination Therapy of Etidronate and Atorvastatin on Atherosclerotic Abdominal Aortic Plaques Detected by Magnetic Resonance Imaging - Open Label Randomized Trial- - The Joetsu Aortic Plaques Prevention Trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000002635
Enrollment
100
Registered
2009-10-17
Start date
2009-11-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperlipidemia, Diabetes, Hypertension

Interventions

Atorvastatin + Etidronate (ATR+ETD) group November 2009-March 2011 Atorvastatin (ATR) group November 2009-March 2011 Etidronate (ETD) group November 2009-March 2011

Sponsors

Niigata-Rousai Hospital
Lead Sponsor
National Institute of Public Health
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Pulse Wave Velocity ≥ 1800 carotid artery echo: plaque score ≥ 3 200 ≥ LDL cholesterol ≥ 160mg/dl Not take an improving drug of lipid metabolism for 3 months. Not take an improving drug of osteoporosis for 3 months Bone Mineral Density > -1SD

Exclusion criteria

Exclusion criteria: The patients who have psychic disturbance, Collagen disease, liver renal dysfunction, heart disorder, cerebrovascular disorder, and or serious complications. The patients who were decided that participation is inappropriate for them by chief physician.

Design outcomes

Primary

MeasureTime frame
The changing rate (%) of hyperplasia in Maximal Wall Thickness after one year ...ATR + ETD group vs. of ATR group—

Secondary

MeasureTime frame
The changing rate (%) of hyperplasia in Maximal Wall Thickness after one year ...ATR + ETD group vs. of ETD group The changing rate (%) of Total Vascular Area and Lumen Area The changing rate (%) of LDLchol value ...ATR + ETD group vs. ATR group, ATR + ETD group vs. ETD group—

Countries

Japan

Contacts

Public ContactTetsuya Kawahara

Niigata-Rousai Hospital Internal Medicine

k-tetsuy@niirou.jp025-543-3123

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026