Patients with hypercholesterolemia
Conditions
Interventions
Pitavastatin 2 mg daily for 12 months.
Sponsors
Nagoya University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with hypercholesterolemia (LDL-C of 140mg/dL or more)
Exclusion criteria
Exclusion criteria: 1) Patients who have taken statins. 2) Patients who have suffered from acute myocardial infarction for the past 3 months. 3) Patients undergoing CABG or PCI for the past 3 months, or planning CABG or PCIin the study periods. 4) Patients with active malignant tumor. 5) Patients with severe renal dysfunction. 6) Patients with severe hepatic dysfunction. 7) Patients with collagen disease. 8) Patients during pregnancy and nursing. 9) Patients who do not accept informed consent. 10) Patients judged as being inappropriate for this study by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in endothelial function (PAT), Change in brachial-ankle pulse wave velocity or cardio-ankle vascular index, Change in intima-media thickness (max IMT, mean IMT) | — |
Secondary
| Measure | Time frame |
|---|---|
| A percent and amount of changes in following factors 1. Serum lipid profile (TC,LDL-C, HDL-C, TG), apolipoprotein (A1, B), beta-lipoprotein, lipoprotein profile by LipoSEARCH, malondialdehyde-modified LDL, CETP 2. high-sensitive CRP, adiponectin, reactive oxygen metabolites (d-ROMs), fasting inslin | — |
Countries
Japan
Contacts
Public ContactKenji Okumura
Nagoya University, Graduate School of Medicine Department of Cardiology
Outcome results
None listed