Chronic kidney disease (CKD)
Conditions
Interventions
After the baseline study, participants received single daily olmesartan in the morning (daily 20mg for 8 weeks). The dosage of olmesartan was increased to the highest dose tolerated, unless their
Sponsors
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences
Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Eligibility criteria include the following: age of 15 years or more; hospitalized in Nagoya City University hospital to undergo a renal biopsy ; diagnosed as having chronic kidney disease (CKD) based on K/DOQI criteria (either kidney damage or glomerular filtration of <60 mL/min/1.73m2 for 3 months or more); and written informed consent was obtained.
Exclusion criteria
Exclusion criteria: Exclusion criteria are as follows; use of inhibitors of renin-angiotensin system or diuretics 1 month before enrollment; specific contraindication to a study drug; presence or possibility of pregnancy; HbA1c of 9.0 % or above; serious liver damage (GOT >100, or GPT >85); secondary hypertension; accelerated or malignant hypertension (progressive renal dysfunction with diastolic BP of >120-130 mmHg); serious congestive heart failure, coronary heart disease, arrhythmia, or systemic diseases; or any reason for ineligibility suggested by the attending doctor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary purpose of this study is to investigate whether there is a positive relationship between the intrarenal activation of renin-angiotensin system (RAS), represented by Angiotensinogen (AGT) expression in the renal-biopsy specimens or urinary excretion of AGT, and night/day ratio of blood pressure, natriuresis or albuminuria, and whether the more intrarenal RAS is activated at baseline, the more the reduction in night/day ratio of blood pressure, natriuresis or albuminuria is. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary purpose of this study is to evaluate whether night/day ratio of urinary excretion rate of AGT shows positive relationship with night/day ratio of blood pressure, natriuresis or albuminuria, and negative one with creatinine clearance and to investigate, in case that the second biopsy is performed, whether the more AGT expression is reduced, the more night/day ratio of blood pressure, natriuresis or albuminuria is decreased. IHC for pro-renin and ACE2 expression is to be studied. | — |
Countries
Japan
Contacts
Public ContactMichio Fukuda
Nagoya City University Graduate School of Medical Sciences Department of Cardio-Renal Medicine and Hypertension
Outcome results
None listed