Comparison of diuretics and Ca antagonist for hypertension with glucose intolerance or dyslipidemia treated with candesartan

Comparison of diuretics and Ca antagonist for hypertension with glucose intolerance or dyslipidemia treated with candesartan - Comparison of combination therapy for hypertension

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002549

Enrollment

Registered

2009-11-01

Start date

2009-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertension

Interventions

candesartan 8mg + trichlormethiazide 0.5 mg or hydrochlorothiazide 6.25 mg candesartan 8mg + amlodipine 5mg

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Hypertensive patients with type 2 diabetes or dyslipidemia or both not reaching the goal of blood pressure according to JSH2009 under the treatment with 8mg of candesartan.

Exclusion criteria

Exclusion criteria: 1. pregnant patients or patients during nursing 2. patients with severe liver dysfunction 3. patients with severe renal dysfunction (eGFR<30) 4. patients with allergy to candesartan, trichlormethiazide, hydrochlorothiazide, or amlodipine

Design outcomes

Primary

Measure	Time frame
blood pressure after 6 months	—

Secondary

Measure	Time frame
1. blood sugar, lipid, and uric acid levels after 6 months 2. adverse effect	—

Countries

Japan

Contacts

Public ContactKoh Ono

Kyoto University Graduate School of Medicine Department of Cardiovascular Medicine

harai@kuhp.kyoto-u.ac.jp075-751-3194

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026