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Targeted radiotherapy for malignant neuroendocrine tumors with I-131 metaiodobenzylguanidine (MIBG)

Targeted radiotherapy for malignant neuroendocrine tumors with I-131 metaiodobenzylguanidine (MIBG) - Targeted radiotherapy for malignant neuroendocrine tumors with MIBG

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000002529
Enrollment
100
Registered
2009-09-18
Start date
2009-09-11
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

malignant neuroendocrine tumors

Interventions

Sponsors

Kanazawa University Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1)patients with histologically proven malignant neuroendocrine tumors 2)patients with metastases, recurrent lesions or unresectable lesions 3)positive I131-MIBg uptake 4)patients with written informed consent 5)patients with ADL adequate for treatment in an isolation room. patients with limited ADL which can be compensated by the others under the approval of the ethical board.

Exclusion criteria

Exclusion criteria: 1)pregnant female and feeding female 2)patients with disturbed consciousness 3)expected life interval less than 1 month 4)limited bone marrow capacity Hb<9.0, WBC count<3,000, platelet count <100,000 5)renal disorder GFR<30 ml/min/1.73 m2 6)risks for the central nerve system during treatment 7)in case that radiation safety cannot be secured. in case with uncontrolled symptoms that may require emergent medical cares. in case that understanding and cooperation cannot be obtained from family members. 8) when medical staff determine that treatment cannot be properly carried out.

Design outcomes

Primary

MeasureTime frame
1)assessment of anti-tumor effects with tumor size and tumor markers 2)assessment of prognosis 3)assessment of symptoms

Countries

Japan

Contacts

Public ContactSeigo Kinuya

Kanazawa University Hospital Department of Nuclear Medicine

kinuya@med.kanazawa-u.ac.jp076-265-2333

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026