Effective of hANP for CABG in patients with moderate to severe preoperative renal dysfunction without dialysis.

Effective of hANP for CABG in patients with moderate to severe preoperative renal dysfunction without dialysis. - NU-HIT trial for CRF

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002499

Enrollment

500

Registered

2009-09-15

Start date

1997-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

myocardial infarction, angina

Interventions

Perioperative administration of hANP Perioperative non-administration of hANP

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patient undergoing isolated CABG eGFR>60 Patients from whom informed consent was obtained

Exclusion criteria

Exclusion criteria: cardiogenic shock dialysis-dependent patient

Design outcomes

Primary

Measure	Time frame
presence of dialysis Cr, eGFR	—

Secondary

Measure	Time frame
reno-event free rate, mortality ,survival rate ,complication, BNP, ANP, renin activity, angiotensin II, aldosterone, blood urea nitrogen (BUN), Cr, sodium (Na), osmotic pressure (Osm),Urinary Na (U-Na), urinary Cr (U-Cr), and osmotic pressure (U-osm) creatinine clearance Ccr, fractional sodium excretion, free water clearance and renal failure index	—

Countries

Japan

Contacts

Public ContactAkira Sezai

Nihon University School of Medicine Department of Cardiovascular Surgery

asezai.med@gmail.com03-3972-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026