The study of specific protein markers in pineal parenchymal tumors

The study of specific protein markers in pineal parenchymal tumors - Pineal parenchymal tumors

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000002471

Enrollment

Registered

2009-09-08

Start date

2009-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pineal parenchymal cell tumors

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The cases of pineal parenchymal tumor The cases of PNET The cases of medulloblastoma The cases without neurologic disease and without pathologic abnormalities

Exclusion criteria

Exclusion criteria: The cases with neurologic disease and without pathologic abnormalities

Design outcomes

Primary

Measure	Time frame
Control tissue, consisting of cerebrum, cerebellum, brain stem, spinal cord, dorsal root ganglion, pineal gland, pituitary gland, thyroid gland, parathyroid gland, adrenal gland, lung, heart, liver, spleen, pancreas, stomach, duodenum, small intestine, colon, kidney, prostate, testis, ovary, and bone marrow, was obtained from patients without neurologic disease and without pathologic abnormalities. Tumor specimens consisted of 8 PPTs (one PC, four PPTIDs, three PB), 3 central nervous system primitive neuroectodermal tumors (PNET), and 8 medulloblastomas (MB). We analyze normal pineal glands, the other human organs, PPTs, and embryonal tumors in CNS by immunohistochemistry for evidence of melatonin synthesis. We further analyse the correlation of the expression of HIOMT with the histological differentiation of PPTs.	—

Measure

Time frame

Control tissue, consisting of cerebrum, cerebellum, brain stem, spinal cord, dorsal root ganglion, pineal gland, pituitary gland, thyroid gland, parathyroid gland, adrenal gland, lung, heart, liver, spleen, pancreas, stomach, duodenum, small intestine, colon, kidney, prostate, testis, ovary, and bone marrow, was obtained from patients without neurologic disease and without pathologic abnormalities. Tumor specimens consisted of 8 PPTs (one PC, four PPTIDs, three PB), 3 central nervous system primitive neuroectodermal tumors (PNET), and 8 medulloblastomas (MB). We analyze normal pineal glands, the other human organs, PPTs, and embryonal tumors in CNS by immunohistochemistry for evidence of melatonin synthesis. We further analyse the correlation of the expression of HIOMT with the histological differentiation of PPTs.

—

Countries

Japan

Contacts

Public ContactTakahiro Fukuda

Research Center for Medical Science, The Jikei University School of Medicine Division of Neuropathology, Department of Neurosciences

fukuda-t@jikei.ac.jp03-3433-1111

Outcome results