Bronchial asthma
Conditions
Interventions
None listed
Sponsors
Kyoto University Graduate School of Medicine
Univs: Osaka City, Kanazawa, Kinki, Kobe, Shiga Med Science, Mie, Kochi, Hiroshima, Fujita Health
Hps &
Clin: Kobe General, Kobe West, Sakai, Hiroshima All &
Resp
Nat. Inst. Public Health
RIKEN Inst.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with stable asthma at least 1 month apart from exacerbations that need rescue bronchodilators or systemic corticosteroids. Patients with asthma who have 3 or more records of pre-or post-bronchodilator FEV1 values obtained during 3 or more years. The first spirometric data was obtained when patients were 25 yr old or more and had been treated with ICS for 1 or more years.
Exclusion criteria
Exclusion criteria: Current smokers or ex smokers with 10 or more pack-years when the first spirometric data was taken. Patients with respiratory diseases other than asthma such as Churg Strauss syndrome, allergic bronchopulmonary aspergillosis, eosinophilic pneumonia, congestive heart disease, vocal cord dysfunction, interstitial pneumonia, bronchiectasia. Patients who are not adherent to ICS treatment (determined by physicians).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association between polymorphsims of candidate genes and annual decline of FEV1 | — |
Secondary
| Measure | Time frame |
|---|---|
| Association of levels of serum markers, and asthma control with annual decline of FEV1. Association of polymorphisms of candidate genes with levels of serum markers and asthma control | — |
Countries
Japan
Contacts
Public ContactHisako Matsumoto
Kyoto University Graduate School of Medicine Department of Respiratory Medicine
Outcome results
None listed