interstitial pneumonitis lung cancer
Conditions
Interventions
After the operation, intravenous infusion of designed amount of urinastatin is administered 9 times in every 8 hours.
Sponsors
Keio University School of Medicine, division of General Thoracic Surgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Histologically confirmed lung cancer 2) cStage IA-IIIB, resectable 3) lung resection is planned 4) the case diagnosed as lung cancer with interstitial pneumonitis by one clinical radiologist in our hospital. The standard of diagnose is below. 1.coin lesion just under the pleura 2.honeycomb lung 3.tractional bronchitis, bronchioles ectasia 4.ground grass opacity 5.consolidation 5)performance status of 0 to 1 6)Adequate hematologic, hepatic, renal, and cardiac function diagnosed within 2 weeks before the registration. *WBC >=3,000/mm3 - <=12,000/mm3 *Absolute neutrophil count 1,500/mm3 - 5000/mm3 *Platelet count >=75,000/mm3 *Hemoglobin >=8.0g/dL *AST and ALT 2.5 times upper limit of normal *Total bilirubin <1.5mg/dL *Creatinine 1.5 times upper limit of normal *ECG normal *SpO2 90% (room air) 7) general anesthesia is permitted 8) Written informed consent
Exclusion criteria
Exclusion criteria: a)asbestosis b)Patients with interstitial pneumonitis caused by connective tissue disease c)chronic hypersensitivity pneumonitis d)sarcoidosis e)Patients who have the history of allergic reactions against urinastatin f)Patients who are pregnant or have possibility of pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Until 1POM, we are going to judge clinically whether adverse outcomes happen, which is thought to be side-effects caused by postoperative ulinastatin therapy. | — |
Countries
Japan
Outcome results
None listed