Effects of the timing of administration of oral small spherical activated charcoal (Kremezin) on the pharmacokinetics and pharmacodynamics of triazolam in humans

Effects of the timing of administration of oral small spherical activated charcoal (Kremezin) on the pharmacokinetics and pharmacodynamics of triazolam in humans - Interaction between activated charcoal and triazolam

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002347

Enrollment

Registered

2009-08-20

Start date

2009-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteers

Interventions

1)triazolam alone,2)simultaneous administration of triazolam and small spherical activated chaecol(Kremezin),3)triazolam administration 60 min after Kremezin,4)triazolam administration 30 min after Kr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)written informed consent before the study 2)volunteers ascertained to be healthy by a medical history, a physical examination, electrocardiogram, whole blood cell counts, serum chemical analysis and urinalysis.

Exclusion criteria

Exclusion criteria: 1)smokers 2)pregnant women 3)nursing women

Design outcomes

Primary

Measure	Time frame
plasma triazolam concentrations subjective drowsiness psychomotor performance (digit symbol substitution test)	—

Countries

Japan

Contacts

Public ContactTsutomu Kotegawa

Oita University Faculty of Medicine Clinical Pharmacology and Therapeutics

kotet@med.oita-u.ac.jp097-586-5952

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026