Hepatocellular carcinoma
Conditions
Interventions
Diet therapy group
Diet + BCAA therapy group
Sponsors
Ministry of Health, Labour and Welfare
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The following HCC patients who are curatively treated with resection or RFA. 1.20 years of age and older. 2.HCV RNA positive liver cirrhosis and 2.8-4.0 g/dl in serum albumin level. 3.New-onset HCC (no extrahepatic lesion, no more than 3lesions and the largest measuring 3cm and below). 4.Clinical diagnosis with imaging tests and tumor markers, add to pathological findings in impossible cases. 5.Comfirmation of no recurrence with CE-CT or CE-US, MRI at a month after treatment.
Exclusion criteria
Exclusion criteria: 1.Impregnated patient 2.Complication of ascites, edema and hepatic coma 3.Intrahepatic cholangiocarcinoma and metastatic liver tumor 4.Patient who is difficult to keep a diet therapy going 5.Insulin-treated diabetic patient 6.HCV negative patient after interferon therapy 7.HBsAg positive patient, heavy user of alcohol (more than 60g/day/ ethanol) 8.Patient who is in treatment with antiviral drug (Interferon, Peg-interforon, Ribavirin, etc) 9.Patient who is complicated with renal dysfunction including dialysis. 10.Patient who is associated with heavy heart, lung and hematological disorder, or others. 11.Inegible patient at a physician's discretion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to recurrence of hepatocellular carcinoma | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival time, Change of hepatic reserve, Change of lipid metabolisum and glucose tolerance, Change of nutritional state, etc | — |
Countries
Japan
Outcome results
None listed