Non-specific
Conditions
Interventions
General anesthesia is induced by midazolam (0.2 mg/kg) after starting continuous infusion of remifentanil (0.1 &
micro
g/kg/min). Tracheal intubation is performed 5 min after induction and the rate of infusion of remifentanil is decreased to 0.05 microg/kg/min.
General anesthesia is induced by midazolam (0.2 mg/kg) af
g/kg/min). Tracheal intubation is performed 5 min after induction and the rate of infusion of remifentanil is decreased to 0.05 microg/kg/min.
Sponsors
Osaka City University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients undergoing operations of the body surface or upper and lower extremities.
Exclusion criteria
Exclusion criteria: Patients with severe liver or renal dysfunction, bronchial asthma, receiving cytochrome P450 inducer or inhibitors, morbid obesity, predicted difficult intubation, seizure, consciousness disturbance, receiving medications affecting electroencephalogram, hypotension, heart failure, coronary artery disease or history of abnormal reactions by midazolam or remifentanil
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure, heart rate, bispectral index, 95% spectral edge frequency | — |
Secondary
| Measure | Time frame |
|---|---|
| electroencephalographic power in delta, theta, alpha and beta band | — |
Countries
Japan
Contacts
Public ContactYutaka Oda
Osaka City University Graduate School of Medicine Department of Anesthesiology
Outcome results
None listed