Ischemic heart disease.
Conditions
Interventions
Add ezetimibe 10mg daily.
Add atorvastatin 10mg daily.
Sponsors
Kameda General Hospital, department of cardiology.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who treated with atorvastatin 10mg daily, and meet all of the following criterias; 1. LDL-Cholesterol over 70mg/dL. 2. Patients with ischemic heart disease. 3. Patients over 20 years old. 4. Patients who do not changed lipid altering agents in 4 weeks. 5. Patients who do not changed antidiabetes agent in 12 weeks, and has no remarkable change in glucose metabolism.
Exclusion criteria
Exclusion criteria: 1. Patients who treated with insulin therapy. 2. HbA1c over 9%. 3. Patients who diagnosed of acute coronary syndrome in one month. 4. Patients who had history of anaphylaxis to the ezetimibe or atorvastatin. 5. AST over 100 IU/l or 127 IU/l. 6. Patients with secondary hyperlipidemia of drug-induced hyperlipidemia. 7. Patients who is pregnant or lactating. 8. Familial hyperlipidemia. 9. Other conditions precluding participation as judged by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percent change of endothelial function. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison between two groups of serum lipid profile, adipocytokine, oxidative-stress and inframmatory marker, expression frequency of adverse effect due to the drugs. | — |
Countries
Japan
Contacts
Public ContactYuya MATSUE, M.D.
Kameda General Hospital. Department of Cardiology.
Outcome results
None listed