Diabetes
Conditions
Interventions
None listed
Sponsors
Tokyo Women's Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Hospitalized patient in Tokyo Women's Medical University with type 1 or insulin-depleted type 2 mellitus (fasting plasma CPR <1microg) 2.Patient who is considered to change insulin therapy because target HbA1c has not been reached and blood glucose level fluctuates wildly in current insulin therapy. 3.A consent form for participating in this study is submitted 4.Males and females of age >= 20 years 5.Patient treated by basal-bolus insulin regimen using rapid-acting insulin analogue (insulin aspart or insulin lispro) and NPH or insulin glargine over 3 months 6.HbA1c >= 8.0 %, <=11.0% 7.BMI <= 26 kg/m2 8.Patient who dose not use sulfonil-urea and pioglitazone
Exclusion criteria
Exclusion criteria: 1.Pregnant, or intention of becoming pregnant. 2.Patients who are judged by investigators as inappropriate subject to participant this trail.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variability during 24 hours (Sum of difference from average blood glucose level) | — |
Secondary
| Measure | Time frame |
|---|---|
| -Difference between maximum blood glucose level and minimum blood glucose level (average of 3 days) -Number of hypoglycemia (BG<=50mg/dL) -Number of hyperglycemia (BG>=300mg/dL) -Change of HbA1c -Change of 1.5AG -Over all adverse events -Circumference of waist and hip -Change of height, weight, BMI -Change of insulin dose (total dose, basal dose, bolus dose) | — |
Countries
Japan
Contacts
Public ContactJunnosuke Miura
Tokyo Women's Medical University Diabetes Center
Outcome results
None listed