Pilot study searching neural correlates of changes in social impairments induced by intranasal oxytocin administration in subjects with autism spectrum disorder

Pilot study searching neural correlates of changes in social impairments induced by intranasal oxytocin administration in subjects with autism spectrum disorder - Pilot study searching changes in brain activation induced by intranasal oxytocin administration in subjects with autism spectrum disorder

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002241

Enrollment

Registered

2009-08-01

Start date

2009-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism spectrum disorder

Interventions

Single intranasal administration of 24 units oxytocin (Syntocinon spray) Single intranasal administration of placebo

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1) Subjects diagnosed with high-functioning autism, Asperger disorder, or pervasive developmental disorder not otherwise specified using Autism Diagnostic Interview-Revised 2) Subjects with normal intelligent (Verbal IQ > 90 and total IQ > 80 measured with Wechsler Adult Intelligent Scale Revised)

Exclusion criteria

Exclusion criteria: 1) History of allergy for oxytocin 2) Cannot enter Magnetic Resonance Scanner 3) History of traumatic brain injury with any known cognitive consequences or loss of consciousness for more than 5 minutes 4) History of substance abuse or addiction 5) Instabilized with psychiatric comorbidity

Design outcomes

Primary

Measure	Time frame
Bold signal changes of functional Magnetic Resonance Imaging	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026