Malignant Pleural Mesothelioma
Conditions
Interventions
Intensity-modurated radiotherapy(IMRT), using 6-10MV X-ray, daily 1.8Gy, 5 days/week until 50.4Gy, but for margin-positive lesions simultaneously boosted to 59.4Gy, after extrapleural pneumonectomy an
Sponsors
Department of Radiation Oncology and Image-Applied Therapy, Kyoto University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Histologically confirmed malignant pleural mesothelioma, any subtypes. 2.Clinical stage I-III, completely resected 3.Several courses of chemotherapy with CDDP and pemetrexed are previously performed. 4.Age <75 5.ECOG PS 0-1 6.Patients with normal contralateral renal function. 7.Patients with no other serious organ dysfunction 8.Patients must sign a study-specific consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with any previous thoracic surgery not intend to complete resection or chemotherapy except for CDDP/pemetrexed. 2.Patients with no adequate reconstoration of diaphragma. 3.Active another neoplasm or previous (wihin 5 years) malignansies 4.Previous radiotherapy to the chest 5.Serious heart disease, arrhythmia, hypofunction of residual lung, uncontrolled infection, pyschological difficulty 6.Uncontrolled diabetes, any complications need steroids therapies. 7.Not suitable for participating in the study for any reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Phase I: Adverse events within 180 days after IMRT. Phase II: Relapse-free survival | — |
Secondary
| Measure | Time frame |
|---|---|
| treatment(radiation therapy) completion rate, pattern of recurrence, overall survival | — |
Countries
Japan
Outcome results
None listed