osteoarthritis of the knee
Conditions
Interventions
daily exercise for 1) muscle strength, and 2) range of motion of the knee
intra-articular injecion of hyaluronate acid.
Sponsors
Juntendo Tokyo Koto Geriatric Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: patients with osteoarthritis of the knee (Kellgren/Lawrence class II or III)
Exclusion criteria
Exclusion criteria: 1) Patients who had treatment for their knee at other hospital or clinic, i.e., who received therapeutic exercise, intraarticular injection, or NSAIDs within 4 weeks before the day to start the trial. 2) Patients who had done or planned operation against the knee. 3) Patients who have diseases requiring regular or intermittent use of steroid or non-steroidal anti-inflammatory drugs. 4) Patients who have articular cartilage injury or history of damage due to obvious trauma or septic arthritis. 5) Patients who were diagnosed as rheumatoid arthritis, gout, pseudogout, or collagen diseases. 6) Patients with cardiac, liver, or renal dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Japanse Knee Osteoarthritis Measure: JKOM 2) measurement of values of blood count, ESR, hs-CRP, HA, IL-1beta, IL-6, IL-10, IL1ra | — |
Secondary
| Measure | Time frame |
|---|---|
| range of motion, local swelling, warmth, hydrops of the affected knee. | — |
Countries
Japan
Contacts
Public ContactYoshiyuki Iwase
Juntendo Tokyo Koto Geriatric Medical Center orthopaedics
Outcome results
None listed