healthy volunteer
Conditions
Interventions
coadministration of acetaminophen and probenecid
administration of acetaminophen alone
Sponsors
APDD
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: the investigors must ensure that all subjects being considerd meet the following inclusion criteria 1) capable to understand and sign the informed consent. 2) 20-45 years of age 3)BMI 18.5-25.0 4)good health as determined by physical examination, vital signs and laboartory tests.
Exclusion criteria
Exclusion criteria: the investigors must ensure that all subjects being considerd meet the following exclusion criteria or conditions 1)peptic ulcer 2)dysemia 3)kidney stone 4)history of cardiac disease 5)imparment of liver or kidney functions 6)any medical condition that reqires medical attention 7) recent (past 4 months) participation in other clinical trial and the investigator determines this trial participation inadequate 8)history of allergy to acetaminophen and probenecid 9)history of aspirin indeced asthma 10)donation of 400mL or more of blood within 3 months prior to participation, donation of 200mL or more of blood within 1 month prior to participation, or donation of component blood within 2 weeks prior to participation 11)positive serologic reaction of syphilis, positive result of HIV test, HBsAg and HCVAb 12)history of multiple and recurring allergies to medicines or food 13)history of drug or alcoholabuse 14) the investigator determines this trial participation inadequate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| detection from radioactive concentraions of plasma, urin and feces samples. | — |
Countries
Japan
Contacts
Public ContactTomoko Kobayashi
Medical Co.LTA Honjo Clinic Honjo Clinic
Outcome results
None listed