A clinical research regarding an inhalation therapy of the low concentration carbon monoxide (CO) in patients with chronic obstructive pulmonary disease (COPD) and secondary pulmonary artery hypertension (sPAH)

A clinical research regarding an inhalation therapy of the low concentration carbon monoxide (CO) in patients with chronic obstructive pulmonary disease (COPD) and secondary pulmonary artery hypertension (sPAH) - A clinical research regarding an inhalation therapy of the low concentration carbon monoxide (CO) in patients with chronic obstructive pulmonary disease (COPD) and secondary pulmonary artery hypertension (sPAH)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002080

Enrollment

Registered

2009-06-16

Start date

2006-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD and sPAH

Interventions

low dose carbon monoxide inhalation (50-100 ppm)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Stabe patients with chronic obstructive pulmonary disease and secondary pulmonary artery hypertension after recovery from acute exacerbation 2.Patients with stage II, III, and IV in GOLD criteria 3.Patients received chronic homeoxygen therapy 4.Patients agreed with written informed consent and to attend this trial with comprehension concerning significance of this research

Exclusion criteria

Exclusion criteria: 1.Patients exposed to high level of ambient CO whose arterial Hb-CO (aHb-CO) concentration was more than 3.0% 2.Current smoker within 4 weeks 3.Patients with cardiac, hepatic, or hematologic diseases 4.Patients with abnormalities of blood coagulation or fibrinolysis

Design outcomes

Primary

Measure	Time frame
Mean pulmonary artery pressure	—

Secondary

Measure	Time frame
Dyspnea scale (Hugh-Jones scale), distance in 6 minutes walking test, lung function, lipid peroxide, and peripheral blood IL-10 level	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026