Multi-center open labeled trial on effects of candesartan on heart rate and blood pressure in the early morning in patients with hypertension

Multi-center open labeled trial on effects of candesartan on heart rate and blood pressure in the early morning in patients with hypertension - Domestic Observation of Heart Rate and Systemic Arterial Blood Pressure in the Morning (DOHSAM study-1)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002079

Enrollment

100

Registered

2009-07-01

Start date

2008-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

In patients with hypertension treating with ARBs other than candesartan with blood pressure more than 135/85 mmHg, we will change ARBs to candesartan and follow up for 1 year. When we change ARBs to

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Hypertensive patients with home blood pressure more than 135/85 mmHg in the early morning.

Exclusion criteria

Exclusion criteria: 1)Patient with allergy to candesartan or amlodipine 2)Pregnant woman or possible pregnant woman 3)Patients with maximal dose of candesartan or amlodipine 4)Patients receiving Ca channel blockers other than amlodipine 5)Patients with atrial fibrillation or its past history

Design outcomes

Primary

Measure	Time frame
Home blood pressure and heart rate in the early morning Ratio of morning and evening blood pressure (M/E ratio)	—

Secondary

Measure	Time frame
Seasonal change in blood pressure	—

Countries

Japan

Contacts

Public ContactShinya Minatoguchi

Gifu university graduate school of medicine Cardiology

minatos@gifu-u.ac.jp058-230-6520

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026