The Influence of Proton Pump Inhibitors on the Antiplatelet Effect of Clopidogrel

The Influence of Proton Pump Inhibitors on the Antiplatelet Effect of Clopidogrel - The Influence of Proton Pump Inhibitors on the Antiplatelet Effect of Clopidogrel

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002060

Enrollment

120

Registered

2009-06-10

Start date

2009-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischemic heart disease

Interventions

the change of administration from 20 mg of omeprazole to 10 mg of rabeprazole the change of administration from 10 mg of rabeprazole to 20 mg of omeprazole control

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients taking omeprazole or rabeprazole, on low-dose (81-100 mg) aspirin and 75 mg of clopidogrel

Exclusion criteria

Exclusion criteria: 1) contraindicative patients of aspirin and clopidogrel, 2) patients with warfarin, 3) patients with thrombolytic therapy within 2 weeks, and 4) patients taking ticlopidine, cilostazole or dipyridamole within 1 month

Design outcomes

Primary

Measure	Time frame
Maximal Platelet Aggregation Rate after intake of PPI	—

Countries

Japan

Contacts

Public ContactToshikazu Jinnai

Kyoto University Department of Cardiovascular Medicine

075-751-4255

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026