Multiple Accumulated Risk Factors Investigation trial associated with the development of Arteriosclelosis

Multiple Accumulated Risk Factors Investigation trial associated with the development of Arteriosclelosis - Multiple Accumulated Risk Factors Investigation trial associated with the development of Arteriosclelosis (MARIA)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000002054

Enrollment

500

Registered

2009-06-10

Start date

2009-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lifestyle-related diseases

Interventions

Antihypertensive agent (ARB, CCB, Diuretics) Hyperlipidemic agent Oral diabetes agent

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Out patients 2.Blood pressure (BP):systolic BP (SBP) 140mmHg and above or diastolic BP (DBP) 90mmHg and above. 3.LDL Cholesterol above 140(mg/dL) 4.HDL Cholesterol below 40(mg/dL) 5.Fasting blood sugar (FBS) level above 126 (mg/dL) 6. HbA1c above 6.5%

Exclusion criteria

Exclusion criteria: 1.Malignant hypertension 2.Pregnant women,or Women suspected of being pregnant. 3.Severe liver disorder. 4.Patients who are inadequate to enter this study due to the other reasons by physician's judgments.

Design outcomes

Primary

Measure	Time frame
1.Clinic blood pressure,heart rate. 2.urinary albumin excretion. 3.plasma BNP. 4.Plasma Insulin 5.LDL-C,TG,HDL-C,BUN,Cr,HbA1cfasting blood glucose	—

Secondary

Measure	Time frame
The influence of the following other risk factors on the early onset in acute myocardial infarction, stroke and death; gender, smoking, hypertension, high TC, high TG, low HDL-C, HOMAR index, BNP, Urinary albumin, eGFR.	—

Countries

Japan

Contacts

Public ContactTakaaki Sakai

College of Healthcare Management Department of Healthcare Management

sakai@minf.med.fukuoka-u.ac.jp0944-67-7007

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026