bronchial asthma
Conditions
Interventions
Isoproterenol Group: Continuous inhalation of l-isoproterenol(0.01 mg/kg/h
12 hours) + placebo salbutamol and systemic steroid therapy
Salbutamon Group: Continuous inhalation of salbutamol(0.5 mg/kg/h
12 hours) + placebo l-isoproterenol and systemic steroid therapy
Sponsors
Dapartment of Pediatrics, Jikei University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Of patients with asthma exacerbation as young as 1 years and as old as 18 years at the time of registration, those with PI (modified pulmonary index) scores of > 14 points without therapy or those with 9 points or more following at least two intermittent (short-acting beta2-agonist: SABA) inhalations within two hours will be enrolled.
Exclusion criteria
Exclusion criteria: Patients with any of the following conditions are excluded: patients with fever (higher than 38.5 centidegree); patients who took an antipyretic drug within six hours; patients with underlying diseases, such as chronic lung disease or cyanotic heart disease, or systemic disease that may cause wheezing; patients with a past history of arrhythmia caused by a beta2-agonist; patients with croup syndrome; patients with suspected foreign-body aspiration; patients with bronchiolitis; patients with pneumonia requiring antibiotic therapy; patients with lobular atelectasis; and patients requiring intratracheal intubation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The degree of change in the mPI scores between baseline and 3 hours after the start of therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) The degree of change in the mPI score between baseline and 12 hours after the start of therapy 2) The degree of change in the respiratory rate between baseline and 3 hours after the start of therapy 3) The degree of change in the heart rate between baseline and 3 hours after the start of therapy 4) The degree of improvement at 3 and 12 hours after the start of therapy | — |
Countries
Japan
Contacts
Public ContactToshio Katsunuma
Jikei Daisan Hospital Dapartment of Pediatrics
Outcome results
None listed