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Clinical trial for effectiveness and safety of granulocyte colony-stimulating factor treatment in patients with acute myocardial infarction

Clinical trial for effectiveness and safety of granulocyte colony-stimulating factor treatment in patients with acute myocardial infarction - G-CSF treatment for left ventricular dysfunction after AMI (GLEAM-2)

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000001987
Enrollment
100
Registered
2009-05-21
Start date
2009-01-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Myocardial Infarction

Interventions

G-CSF treatment Placebo treatment

Sponsors

Department of Cardiovascular Science and Medicine Chiba University Graduate School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients were eligible if they were admitted within 12 h after onset of AMI with total occlusion of single coronary artery and underwent successful PCI. Diagnosis of AMI was achieved with continuous chest pain over 30 min, and/or ST elevation over 0.1mV in more than 2 extremity leads, and/or ST elevation over 0.2mV in more than 2 chest leads

Exclusion criteria

Exclusion criteria: 1) Patients who have uncontrolled myocardial ischemia after PCI 2) Patients who ara suspected to have acute coronary occlusion 3) Patients who are in cardiac shock 4) Patients who have malignant diseases 5) Patients who have diabetic retinopathy 6) Patients who have severe drug allergy 7) When informed concent is not obtained from patients 8) When doctors decide that patients do not have eligibility for this study

Design outcomes

Primary

MeasureTime frame
reduction of infarct area

Secondary

MeasureTime frame
inhibition of cardiac remodeling after MI inhibition of cardiac dysfunction after MI reduction of cardiovascular event, such as cardiac sudden death, non-fatal MI, unstable angina, hospital admission due to heart failure, and lethal arrhythmia

Countries

Japan

Contacts

Public ContactHiroyuki Takano

Chiba University Hospital Departmento of Cardiology

043-226-2555

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026