A randomized, double blind, comparative study of vitamin D3 versus placebo in patients with cancer in gastrointestinal tract to prevent relapse after operation

Conditions

cancers in gastrointestrinal tract esophageal cancer, gastric cancer, colon cancer

Soichiro Fukuzato, Hironori Ohdaira, Yutaka Suzuki, Mitsuyoshi Urashima

Nutrients2024-03-224 citations

10.3390/nu16070921

Effect of Vitamin D Supplements on Relapse or Death in a p53-Immunoreactive Subgroup With Digestive Tract Cancer

Kazuki Kanno, Taisuke Akutsu, Hironori Ohdaira, Yutaka Suzuki, Mitsuyoshi Urashima

JAMA Network Open2023-08-2229 citations

10.1001/jamanetworkopen.2023.28886

Effect of Vitamin D Supplements on Relapse of Digestive Tract Cancer with Tumor Stromal Immune Response: A Secondary Analysis of the AMATERASU Randomized Clinical Trial

Taisuke Akutsu, Kazuki Kanno, Shinya Okada, Hironori Ohdaira, Yutaka Suzuki et al. (6 authors)

Cancers2021-09-204 citations

10.3390/cancers13184708

Effect of Serum SPARC Levels on Survival in Patients with Digestive Tract Cancer: A Post Hoc Analysis of the AMATERASU Randomized Clinical Trial

Taisuke Akutsu, Eisaku Ito, Mitsuo Narita, Hironori Ohdaira, Yutaka Suzuki et al. (6 authors)

Cancers2020-06-0413 citations

10.3390/cancers12061465

Effect of Vitamin D Supplementation on Survival of Digestive Tract Cancer Patients with Low Bioavailable 25-Hydroxyvitamin D Levels: A Post Hoc Analysis of the AMATERASU Randomized Clinical Trial

Mitsuyoshi Urashima, Mai Okuyama, Taisuke Akutsu, Hironori Ohdaira, Mutsumi Kaji et al. (6 authors)

Cancers2020-02-0420 citations

10.3390/cancers12020347

Effect of Vitamin D on Relapse-Free Survival in a Subgroup of Patients with p53 Protein–Positive Digestive Tract Cancer: A <i>Post Hoc</i> Analysis of the AMATERASU Trial

Taisuke Akutsu, Shinya Okada, Shinichi Hirooka, Masahiro Ikegami, Hironori Ohdaira et al. (7 authors)

Cancer Epidemiology Biomarkers & Prevention2019-12-2313 citations

10.1158/1055-9965.epi-19-0986

Effect Modification of Vitamin D Supplementation by Histopathological Characteristics on Survival of Patients with Digestive Tract Cancer: Post Hoc Analysis of the AMATERASU Randomized Clinical Trial

Hideyuki Yonaga, Shinya Okada, Taisuke Akutsu, Hironori Ohdaira, Yutaka Suzuki et al. (6 authors)

Nutrients2019-10-2215 citations

10.3390/nu11102547

Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers

Mitsuyoshi Urashima, Hironori Ohdaira, Taisuke Akutsu, Shinya Okada, Masashi Yoshida et al. (7 authors)

JAMA2019-04-09139 citations

10.1001/jama.2019.2210

Interventions

vitamin D3 supplement placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. First operation for cancer of gastrointestinal tract at International University of Health and Welfare hospital 2. Obtained informed consent

Exclusion criteria

Exclusion criteria: 1. Already taking vitamin D supplement or 1,25 vitamin D 2. History of kidney stone 3. Other difficulties judged by the surgeon in charge

Design outcomes

Primary

Measure	Time frame
relapse free survival overall survival	—

Countries

Japan

Contacts

Public ContactEmi Suzuki

Jikei University School of Medicine Division of Molecular Epidemiology

emisuzu@jikei.ac.jp

Outcome results

None listed