Clinical effectiveness of Donepezil Hydrochloride for radiation-induced memory disturbance in patients with brain tumor

Clinical effectiveness of Donepezil Hydrochloride for radiation-induced memory disturbance in patients with brain tumor - Clinical effectiveness of Donepezil Hydrochloride for radiation-induced memory disturbance in patients with brain tumor

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001945

Enrollment

Registered

2009-06-01

Start date

2009-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain tumor

Interventions

Donepezil Hydrochloride

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. no history of radiation therapy to brain 2. expect more than 6 months survival 3. patiets with small cell lung cancer who will receive prophylactic cranial irradiation 4.patiets with multiple brain tumors, without midline shift, nor without huge tumors of more than 5cm diameter 5.patients without disease of contra-indication to Donepezil Hydrochloride

Exclusion criteria

Exclusion criteria: Patients of contra-indication to Donepezil Hydrochloride

Design outcomes

Primary

Measure	Time frame
Improvement of memory disturbance	—

Countries

Japan

Contacts

Public ContactYasuo Ejima

Kobe University Hospital Division of Radiation Oncology

ejimay@med.kobe-u.ac.jp078-382-6104

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026