The patients who were planned to hepatic resection in the Department of Digestive Surgery at Nihon University Itabashi Hospital, Tokyo, Japan.
Conditions
Interventions
The patients were assigned randomly to a control group or a steroid group in which patients received 500mg of hydrocortizon just before hepatic pedicle clamping, 300mg on postoperative day (POD) 1, 20
Sponsors
Nihon University School of Medicine, Itabashi Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Eligibility criteria included from 15 to 84 years patients who were planned to hepatic resection and had adequate functional reserve of the heart, lungs, and kidneys. Patients were excluded who if they had already treated with taken steroids, had unstable condition of gastric ulcer or past history of acute myocardial infarction. Randomization stratified by Child-Pugh class (A or B)
Exclusion criteria
Exclusion criteria: Eligibility criteria included from 15 to 84 years patients who were planned to hepatic resection and had adequate functional reserve of the heart, lungs, and kidneys. Patients were excluded who if they had already treated with taken steroids, had unstable condition of gastric ulcer or past history of acute myocardial infarction. Randomization stratified by Child-Pugh class (A or B)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint was serum level of total bilirubin (T.bil) on POD2. | — |
Secondary
| Measure | Time frame |
|---|---|
| The other serum levels related to liver function, inflammatory cytokine levels, and postoperative complications were also compared between the two groups. | — |
Countries
Japan
Contacts
Public ContactShintaro Yamazaki
Nihon University School of Medicine Department of Digestive Surgery
Outcome results
None listed