Gastric cancer patients who underwent total gastrectomy.
Conditions
Interventions
ghrelin group (+) ghrelin administration postoperative 10-days twice a day before breakfast and before dinner
Intervention B
placebo group (-) saline administration postoperative 10-days twice a day before breakfast and before dinner
Sponsors
Osaka University School of Medicine Gastroenterological Surgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The inclusion criteria were as follows: 1) adenocarcinoma of the stomach confirmed by histopathological examination, 2) preoperative clinical staging with less than stage II (UICC TNM stage classification), 3) curative surgical treatment (R0), i.e., TG with D1 or D2 lymph node dissection, and 4) Age >20 and <80 years.
Exclusion criteria
Exclusion criteria: The exclusion criteria were the presence of any of the following; 1) cardiopulmonary, liver or renal dysfunction, 2) active dual malignancy, 3) pregnancy, 4) past history of gastrointestinal surgery, 5) postoperative complications after TG that could affect oral food intake, such as anastomotic leakage, pancreatitis and ileus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Food intake calories (during 10-days ghrelin administration) | — |
Secondary
| Measure | Time frame |
|---|---|
| appetite VAS, postoperative body weight, postoperative BMI (during 10-days ghrelin administration) | — |
Countries
Japan
Contacts
Public ContactShuji Takiguchi
Osaka University School of Medicine Gastroenterological Surgery
Outcome results
None listed