preventive effects of isosorbide dinitrate / nicorandil on myocardial ischemia during postoperative period in patients with coronary risk underwent non-cardiac surgeries

preventive effects of isosorbide dinitrate / nicorandil on myocardial ischemia during postoperative period in patients with coronary risk underwent non-cardiac surgeries - preventive effects of isosorbide dinitrate / nicorandil on myocardial ischemia during postoperative period in patients underwent non-cardiac surgeries

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001915

Enrollment

300

Registered

2009-05-21

Start date

2009-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperrative ischemic heart disease(postoperative)

Interventions

non-treatment with vasodilators, anti-anginal agents during staying in intensive care unit ISDN (0.5micro-g/kg/min) nicorandil(0.6micro-g/kg/min)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients undergoing non-cardiac surgeries who are evaluated into classes of ASA 1/2 and have over 10 points of coronary risk index

Exclusion criteria

Exclusion criteria: contraindication to medicines treatment with beta blockers before surgery

Design outcomes

Primary

Measure	Time frame
myocardial ischemia(ECG), arrhythmia, symptoms of heart failure, chest pain, heart attack	—

Secondary

Measure	Time frame
adverse effect	—

Countries

Japan

Contacts

Public ContactMisumi Takuyo

Kobe University Hospital Department of Intensive Care Unit

misumi@med.kobe-u.ac.jp078-382-5111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026