Chronic kidney disease, Ischemic heart disease
Conditions
Interventions
None listed
Sponsors
Cardiovascular research foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Age above 20 2) Chronic kidney disease with following A and/or B A. Below estimated glomerular filtration(eGFR)50mL/min/1.73m2 B. Serum creatinine concentration over1.5mg/dL(Male), 1.2mg/dL(Female) 3) Patient with at least one or more following risk factors: Hypertension, Diabetes, hyperlipidemia, Peripheral artery disease , Current smoking, Family history of coronary heart disease, history of stroke 4) Possible to SPECT study within 2 months before or after registration 5) Patients who are obtained informed consent 6) Patients with following symptom or findings but not confirmed definitive diagnosis: A. Angina or equivalent symptoms B. Suspected ischemic heart disease with new breath shortness or pulsation C. Suspected ischemic heart disease by electric cardiogram
Exclusion criteria
Exclusion criteria: 1) patients with dialysis or peritoneal dialysis 2) valvular disease nessesary to operation 3) HCM or DCM 4) History of myocardial infarction or angina before registration. Hiiistory of revascularization. 5) Coronary angiography or CT angiography within 2 months before registration 6) drug hypersensitivity with Tetrofosmin or analogous drug 7) Difficult to study Gated SPECT due to arrhythmias 8) Contraindication of adenosine such as spasmodic asthma 9) Unsuitable for registration by investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac death, Sudden death | — |
Secondary
| Measure | Time frame |
|---|---|
| on fatal myocardial infarction, first hospitalization for heart failure or unstable angina, stroke, coronary or peripheral revascularization. Performed PCI or CABG, Introduce dialysis, the first event of the composite end point of a doubling of the serum creatinine concentration. | — |
Countries
Japan
Outcome results
None listed