chronic liver disease
Conditions
Interventions
Combination of 12g of daily branched-chain amino acid supplementation (Aminofeel)and controlled exercise therapy along with 6 weeks of nutritional support including late evening snack
12g of daily b
Sponsors
Tohoku University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients with muscle atrophy 2.Serum albumin concentration =<4g/dl 3.Serum branched-chain amino acid/tyrosine molar ratio (BTR) =< 4.41 4.Patients who give documentary informed consent voluntarily
Exclusion criteria
Exclusion criteria: 1.Patients with poor oral intake 2. Pasthistory of allergic reaction to the ingredients of Aminofeel 3.Patients with risky varices for upper GI bleeding 4. Patients of diabetes with poor control of the concentration of blood sugar 5. Patients of hypertention with poor control of blood pressure 6. Patients with history of severe cardiovascular diseases 7.Patients with clinical manifestation of hepatic encephalopathy 8.Patients inappropriate for participating to this study decided by the attending physicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nutritional status after 6 weeks from the registration | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptoms, quality of life of patients and immunological competences after 6 weeks from the registration | — |
Countries
Japan
Contacts
Public ContactKoji Fukushima
Tohoku University Hospital Division of Gastroenterology
Outcome results
None listed