Acute myocardial infarction
Conditions
Interventions
Intraveous landiolol administation
Placebo
Sponsors
Cardiovascular Division, University of Tsukuba, Graduate School of Comprehensive Human Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) chest pain more than 30 min 2) 0.1mV ST-segment elevation in 2 contiguous ECG leads 3) admission to hospital within 12 hours of symptom onset 4) tachycardia of more than 80 beats/min 5) First episode of anterior STEMI 6) emergent primary percutaneous coronary intervention
Exclusion criteria
Exclusion criteria: 1) history of OMI or CABG 2) LMT 3) suspected aortic dissection 4) systolic blood pressure of less than 90 mmHg or bradycardia of less than 60 beats/min 5) more than II-AV block or 2 bundle block 6) severe liver and/or kidney dysfunction 7) bronchial athma 8) history of beta-blocker or amiodarone 9) history of side effects or contraindication of beta-blocker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Estimated infarct size (AUC of creatine kinase) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Estimated infarct size (AUC of CK-MB) 2) Infarct size on 99mTc-MIBI SPECT | — |
Countries
Japan
Contacts
Public ContactAkira Sato
University of Tsukuba, Graduate School of Comprehensive Human Sciences Cardiovascular Division
Outcome results
None listed