Evaluation of the effect of AngiotensinII receptor blocker on coronary artery after Sirolimus-Eluting Stent implantation

Evaluation of the effect of AngiotensinII receptor blocker on coronary artery after Sirolimus-Eluting Stent implantation - Evaluation of the effect of AngiotensinII receptor blocker on coronary artery after Sirolimus-Eluting Stent implantation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001822

Enrollment

Registered

2009-03-31

Start date

2008-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension with coronary artery disease

Interventions

Telmisartan + Fluvastatin sodium Long-acting calcium channel blocker + Fluvastatin sodium

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: "1) Patients after Sirolimus-Eluting stent implantation 2) Patients with eligible stenosis (including restenosis) for PCI in 1-2 branch and no stenosis in non-target branch 3) Lesions diameter are 2.5-4.0mm and lesions length are treated by 1 SES 4) Patients who are eligible for IVUS and OCT examinations 5) Hypertensive Patients"

Exclusion criteria

Exclusion criteria: "1) Patients with coronary vasospasm 2) Patients who have lesions that are applicable to exclusion criteria 3) Previous cerebrovascular event <= 6month 4) Severe gastrointestinal bleeding <= 3month 5) Patients who contraindicate antithronbotic and anticoagulant therapy 6) Patients who have severe allergy to contrast dye 7) Ejection fraction <= 30%"

Design outcomes

Primary

Measure	Time frame
Endothelial function by acetylcholine infusion at 3 and 9months follow-up after Sirolimus-Eluting Stent(SES) implantation	—

Secondary

Measure	Time frame
1) Intima proliferation and vascular healing of lesion that SES implantation by Optical Coherence Tomography(OCT)at 9months follow-up 2) Plaque composition of non-target lesion by Virtual Histology IVUS at 9months follow-up 3) Coronary collateral function by flow Pressure combination wire at 3 and 9months follow-up 4) Change in surrogate marker TNF-alpha,hs-CRP,IL-6,Adiponectin,Total, LDL, HDL-Cho,Triglyceride,Sitosterol,Campesterol,Lathosterol,Apo A-1,Apo B,Apo E	—

Measure

Time frame

1) Intima proliferation and vascular healing of lesion that SES implantation by Optical Coherence Tomography(OCT)at 9months follow-up 2) Plaque composition of non-target lesion by Virtual Histology IVUS at 9months follow-up 3) Coronary collateral function by flow Pressure combination wire at 3 and 9months follow-up 4) Change in surrogate marker TNF-alpha,hs-CRP,IL-6,Adiponectin,Total, LDL, HDL-Cho,Triglyceride,Sitosterol,Campesterol,Lathosterol,Apo A-1,Apo B,Apo E

—

Countries

Japan

Contacts

Public ContactMitsuiyasu Terashima

Toyohashi Heart Ceter Cardiovascular Medicine

0532-37-3377

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026