Metastatic chemo naive colorectal cancer
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Histological proven colorectal cancer 2. PS:0 to 1(ECOG performance status score) 3. One or more RECIST lesions 4. chemo-naive 5. Good function of critical organs 6. Suspect for more than 3 months alive 7. Written informed consents
Exclusion criteria
Exclusion criteria: 1. Severe heart diseases 2. Wish for pregnancy 3. Active infection 4. Steroid or immunosuppressive therapy 5. Allergy for using epitope peptides 6. Mental and nervous disorder 7. Massive pleural or abdominal effusions 8. Peripheral nervous disorder 9. Diarrhea 10. Doctors opinion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the efficacy (response rate, time to progression) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Safety 2. Over all survival 3. Induction of immune responses 4. Progression free survival | — |
Countries
Japan
Contacts
YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE Department of Digestive Surgery and Surgical Oncology