Achieved timing of nocturnal BP dip by negative sodium balance with diuretics in CKD: comparison between diuretics alone and its combination with ARB.

Achieved timing of nocturnal BP dip by negative sodium balance with diuretics in CKD: comparison between diuretics alone and its combination with ARB. - Achieved timing of nocturnal BP dip by negative sodium balance.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001788

Enrollment

Registered

2009-03-24

Start date

2009-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease (CKD)

Interventions

1) Pre-intervention, 2) diuretics (HCTZ 12.5mg) once in the morning for a week, and then, 3) combination of diuretics (HCTZ 12.5mg) with angiotensin II blocker (losartan 50mg) once in the morning for

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Eligibility criteria include the following: 15 years of age or older; hospitalized in Nagoya City University hospital; diagnosed as having chronic kidney disease (CKD) based on K/DOQI criteria (either kidney damage or glomerular filtration of <60 mL/min/1.73m2 for 3 months or more); and written informed consent was obtained.

Exclusion criteria

Exclusion criteria: Exclusion criteria are as follows; use of inhibitors of renin-angiotensin system or diuretics 1 month before enrollment; specific contraindication to a study drug; HbA1c of 9.0 % or above; serious liver damage (GOT >100, or GPT >85); secondary hypertension; accelerated or malignant hypertension (progressive renal dysfunction with diastolic BP of >120-130 mmHg); serious congestive heart failure, coronary heart disease, arrhythmia, or systemic diseases; presence or possibility of pregnancy; or any reason for ineligibility suggested by the attending doctor.

Design outcomes

Primary

Measure	Time frame
Duration in days since diuretics alone, or in combination with ARB, are administered until nocturnal BP becomes lower than 90% of daytime averages.	—

Secondary

Measure	Time frame
Changes in the night/day ratio of urinary albumin excretion, 24-h BP, glomerular filtration rate, daily urinary albumin excretion, HbA1c, and serum uric acid, or any adverse event	—

Countries

Japan

Contacts

Public ContactMichio Fukuda

Nagoya City University Graduate School of Medical Sciences Department of Cardio-Renal Medicine and Hypertension

m-fukuda@med.nagoya-cu.ac.jp052-853-8221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026