cholangiocarecinoma:Stage III and IV of the Japanese General Rules for Surgical and Pathological Studies on Cancer of the Biliary Tract
Conditions
Interventions
chemoradiation EXRT: 45Gy, 1.8Gy x 25 fr Gemcitabine : 600mg/m2
Sponsors
Hepato-biliary pancreatic surgery,Tohoku University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Histologically confirmed as cholangiocarcinoma. And Stage III and IV by the Japanese General Rules for Surgical and Pathological Studies on Cancer of the Biliary Tract 2. Performancestatus(ECOG) is 0 or 1 3. Age are from 20 years old to 74 yeas old 4. survival is expected over 2 months 5. Function of main organ are enough as below, Hb over 10 g/dl. WBC is over 4000/mm3. Neutrophil is over 2000/mm3. Platlet is over1x104mm3. AST and ALT are within 5 times of normal limit. Total bilirubin is within 3 times of normal limit. Creatinine is 1.5 times within normal limit. 6. sign the letter of consent by voluntary agreement
Exclusion criteria
Exclusion criteria: 1. obvious infection 2. fever up (over 38 Celsius) 3. severe complication of heart and lung 4. active double cancer 5. synptom of brain metastases 6. pericardial fluid 7. Previous history of severe drug-induced allergy 8. Pregnant 9. Disqualified by attendig doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pathological curability | — |
Secondary
| Measure | Time frame |
|---|---|
| safety, disease free survival, over all survival, pathological response | — |
Countries
Japan
Contacts
Public ContactKei Nakagawa
Tohoku University Hospital Hepato-biliary pancreatic surgery,
Outcome results
None listed