Short-term antibiotic therapy for acute cholangitis after successful endoscopic biliary drainage

Short-term antibiotic therapy for acute cholangitis after successful endoscopic biliary drainage - Short-term antibiotic therapy for acute cholangitis after successful endoscopic biliary drainage

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001705

Enrollment

Registered

2009-02-13

Start date

2007-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute cholangitis

Interventions

Intravenous antibiotics therapy for patients diagnosed with acute cholangitis is started immediately. When &lt

37 degrees body temperature is maintained for 24 hrs, administration of antibiotics is stopped.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Patients with "moderate" or "severe" acute cholangitis, which is defined by "Tokyo Guidelines for the management of acute cholangitis and cholecystitis" and received biliary drainage within 24 hrs after diagnosis 2)Patients of age >= 20 years 3)Written informed consent is reqired from all patients.

Exclusion criteria

Exclusion criteria: 1)Patients with the most severe cholangitis requiring catecholamine administration, mechanical ventilation management, or hemodialysis 2)Patients with acute pancreatitis 3)Patients with other active concomitant infections 4)Patients without adequate drainage due to remaining biliary strictures 5)Patients who have undergone biliary stenting or percutaneous biliary drainage 6)Patients with sclerosing cholangitis 7)Patients with previous choledochojejunostomy 8)Patients with previous heart valve replacement 9)Patients with severe cardiovascular disease 10)Patients receiving maintenance hemodialysis 11)Patients with previous history of antibiotic hypersensitivity 12)Patients receiving chemotherapy 13)Patients receiving steroid or immunosuppressive agent 14)Patients who have received antibiotics within 4 weeks before the pre-observation period 15)Inappropriate patients for entry on this study by the judgement of the investigators

Design outcomes

Primary

Measure	Time frame
recurrence rate of cholangitis 3 days after withdrawal of antibiotic therapy	—

Secondary

Measure	Time frame
1)Period until normalization of inflammation markers (WBC and CRP) 2)Incidence of complications (liver abscess and sepsis, etc.) related to cholangitis 3)Readministration rate of antibiotics 4)medical costs	—

Countries

Japan

Contacts

Public ContactHirofumi Kogure

Faculty of Medicine, University of Tokyo Department of Gastroenterology

03-3815-5411

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026