rectal cancer,lower tumor margin is below the peritoneal reflection
Conditions
Interventions
UFT 300mg/m2/day 1-5,8-12,15-19,22-26 Radiotherapy 2gy 5days a week for 4weeks
-1 80mg/m2/day 1-5,8-12,15-19,22-26 Radiotherapy 2gy 5days a week for 4weeks
Sponsors
Tokushima university
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1,histologically confirmed rectal cancer 2,clinical stage T1-T4 for EUS or CT 3,lower tumor margin is below the peritonal reflection 4,weasurable resion 5,no evidence of peritoneal metastasis 6,age 20-74 years old 7,performance status(ECPG) 0-2 8,possible to 3month survival 9,adequate organ function 10,no prior oparation,chemotherapy,radiotherapy 11,written informed concent 12,the case can eat
Exclusion criteria
Exclusion criteria: 1,apparent or previous history of interstitinal pneumonitis or pulmonary fibrosis 2,pleural effusion or ascites requiring treatment 3,multiple malignancies 4,infection,paralysis of intestine or ireus 5,diarrhea(watery stool) 6,uncontrollacle diabetes 7,severe complication(heart failure,renal failure,hepatic insufficiency) 8,brain metastasis or treated brain metastasis 9,preqnant or lacting,capable of preqnancy or intend to get preqnant 10,previus serius medical illness or allergy for drug 11,critical mental disturbance 12,systemically administrered of steroids 13,judged in appropriate for this study by the physycians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| response rate | — |
Secondary
| Measure | Time frame |
|---|---|
| pathological complete response rate pathological response rate adverse event overall survival | — |
Countries
Japan
Outcome results
None listed