A pilot randomized placebo controlled study of the Neutrophil Elastase Inhibitor, Sivelestat, in Patients Undergoing Cardiac Surgery

A pilot randomized placebo controlled study of the Neutrophil Elastase Inhibitor, Sivelestat, in Patients Undergoing Cardiac Surgery - A pilot randomized placebo controlled study of the Neutrophil Elastase Inhibitor, Sivelestat, in Patients Undergoing Cardiac Surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001687

Enrollment

Registered

2009-02-05

Start date

2004-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery bypass patients

Interventions

Continuous intravenous administration of the neutrophil erastase inhibitor Continuous intravenous administration of isotonic sodium chloride solution

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients scheduled for elective, isolated on-pump coronary artery bypass

Exclusion criteria

Exclusion criteria: Patients requiring either preoperative intravenous inotropic or vasodilative drugs, intraaortic balloon support, supplemental oxygen, or mechanical ventilation

Design outcomes

Primary

Measure	Time frame
Completeness of the study in enrolled patients. Peri-operative morbidity	—

Secondary

Measure	Time frame
Clinical outcomes such as lenghts of hospital stay. Pulmonary function	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026