Multicenter cohort study to investigate the risk of metachronous multiple cancers and assess the period required for their development after EMR, using Lugol-voiding pattern as a biomarker in patients with esophageal squamous cell carcinoma

Conditions

Esophageal squamous cell carcinoma

Hori K, Katada C, Okada H, Katagiri A, Matsuo Y, Yokoyama T, Yano T, Suzuki H, Shimizu Y, Furue Y, Nakanishi H, Koike T, Takizawa K, Hirao M, Yoshii T, Yamanouchi T, Kawakubo H, Kobayashi N, Shimoda T, Ochiai A, Ishikawa H, Yokoyama A, Muto M.

2023-12-095 citations

10.1007/s10388-023-01033-9

Metachronous primary gastric cancer after endoscopic resection in patients with esophageal squamous cell carcinoma.

Hirao M, Katada C, Yokoyama T, Yano T, Suzuki H, Furue Y, Yamamoto K, Doyama H, Koike T, Tamaoki M, Kawata N, Kawahara Y, Katagiri A, Ogata T, Yamanouchi T, Kiyokawa H, Kawakubo H, Konno M, Ishikawa H, Yokoyama A, Muto M.

2023-06-274 citations

10.1007/s10120-023-01413-1

Field Effect of Alcohol, Cigarette Smoking, and Their Cessation on the Development of Multiple Dysplastic Lesions and Squamous Cell Carcinoma: A Long-term Multicenter Cohort Study

Manabu Muto, Chikatoshi Katada, Akira Yokoyama, Tomonori Yano, Ichiro Oda et al. (44 authors)

Gastro Hep Advances2022-01-0112 citations

10.1016/j.gastha.2021.10.005

The Alcohol Use Disorders Identification Test and the risk of metachronous cancer after endoscopic resection of esophageal cancer

Akira Yokoyama, Chikatoshi Katada, Akira Yokoyama, Kohei Takizawa, Tomonori Yano et al. (19 authors)

Carcinogenesis2020-03-079 citations

10.1093/carcin/bgaa022

Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions

Chikatoshi Katada, Akira Yokoyama, Tomonori Yano, Ichiro Oda, Yuichi Shimizu et al. (17 authors)

Diseases of the Esophagus2020-02-1212 citations

10.1093/dote/doz110

Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer.

Yokoyama A, Katada C, Yokoyama T, Yano T, Kaneko K, Oda I, Shimizu Y, Doyama H, Koike T, Takizawa K, Hirao M, Okada H, Yoshii T, Konishi K, Yamanouchi T, Tsuda T, Omori T, Kobayashi N, Suzuki H, Tanabe S, Hori K, Nakayama N, Kawakubo H, Ishikawa H, Muto M.

2017-04-0624 citations

10.1371/journal.pone.0175182

Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck

Chikatoshi Katada, Akira Yokoyama, Tomonori Yano, Kazuhiro Kaneko, Ichiro Oda et al. (25 authors)

Gastroenterology2016-08-01201 citations

10.1053/j.gastro.2016.07.040

Interventions

At study entry, patients will be instructed to abstain from smoking and drinking alcohol.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Newly diagnosed early squamous cell carcinoma of the esophagus. (2) Complete endoscopic resection as assessed visually on Lugol chromoendoscopy immediately after EMR. (3) A diagnosis of squamous cell carcinoma on histopathological examination of the resected specimen. (4) Vertical margins of the resected specimen are confirmed to be tumor-negative. (5) Tumor invasion is limited to the mucosa on histopathological examination of the resected specimen, and no additional treatment (surgical resection, radiotherapy, chemotherapy, etc.) is performed immediately after EMR. (6) No active head or neck cancers. (7) The investigator judges that patient can be observed for at least 2 years. (8) Written informed consent is obtained from the patient.

Exclusion criteria

Exclusion criteria: (1) A history of chemotherapy for any other cancers or a history of surgical treatment or radiotherapy for head and neck cancers. (2) A history of iodine allergy. (3) Patients whom the investigator considers unsuitable as subjects for this study.

Design outcomes

Primary

Measure	Time frame
The cumulative incidence of metachronous multiple cancers of the esophagus as assessed by the Lugol-voiding pattern.	—

Secondary

Measure	Time frame
1) The total annual number of cases of metachronous multiple cancer of the esophagus as assessed by the Lugol-voiding pattern. 2) The cumulative incidence of metachronous multiple cancers of the head and neck region as assessed by the Lugol-voiding pattern.	—

Countries

Japan

Contacts

Public ContactChikatoshi Katada

Kitasato University Hospital Department of Gastroenterology

ckatada@med.kitasato-u.ac.jp042-778-8111

Outcome results

None listed