Huntington'
Conditions
Interventions
Step1. Treated with yokukansan 12 weeks Step2. Wash out 12 weeks
Step1. 12 weeks waiting period Step2. Treated with yokukansan 12 weeks
Sponsors
Dept. Nerol and Center for traditional Asian medicine, Tohoku University Graduate school of medicine
Ntional hospital organization Yonezawa hospital Nishitaga national hospital Osaka prefectural hospital organization, medical center National center of neurology and psychiatry
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Clinically diagnosed as Huntington's disease according to ICD10 with abnormal prolongation of CAG repeat in IT15 gene. 2. At least one subscore of UHDRS is more than 3. 3. Serum potassium level is within the normal limit. 4. The patients have symptoms agreed to use yokukansan with public medical insurance in Japan. It includes irritation, quick tempered, hypersensitivity and insomnia.
Exclusion criteria
Exclusion criteria: 1. With any malignancy 2. With severe heart disease, liver disease, blood disease, respiratory disease and any other severe diseases influenced on the patients states 3. With any neurodegenerating diseases other than Huntington's disease 4. Alcohol abuse, drug abuse, metabolic toxicity, chronic inflammatory diseases 5. Who can not take the herbal medicine. 6. Who are perscribed any antipsychotics newly in the observation period. 7. Others who are judged as inadequate by attending doctors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Huntington's Disease Rating Scale (UHDRS) Neuropsychiatric Inventry(NPI) | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function, ADL, Use of rescue drug, toralance | — |
Countries
Japan
Contacts
Public ContactKoh Iwasaki
Tohoku University Graduate school of medicine Center for Asian Traditional Medicine
Outcome results
None listed