Japanese cedar pollinosis
Conditions
Interventions
Botulinum toxin A (20 U, 0.2ml) is injected into each nasal cavity just before the beginning of pollen scattering. Ten mg of loratadine and/ or mometazone nasal spray can be used as a backup drug.
S
Sponsors
Department of Otorhinolaryngology, Head and Neck Surgery Faculty of Medicine, University of Yamanash
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)a history of Japanese cedar pollinosis 2)CAP-RAST against Japanese cedar pollen ≥2
Exclusion criteria
Exclusion criteria: 1)pregnancy or possibility of pregnancy 2)history of heart disease 3)history of glaucoma 4)history of prostate hypertrophy 5)history of neuro-muscular disease 6)history of stroke 7)accompanying acute rhinitis or sinusitis 8)use of any anti-allergy drugs at the beginning of the study 9)history of nose/sinus surgery 10)prominent deviation of the nasal septum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptom score, symptom-medication score, QOL estimation, rhinomanometry | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse events | — |
Countries
Japan
Contacts
Public ContactAtsushi Kamijo
University of Yamanashi Department of Otorhinolaryngology, Head and Neck Surgery
Outcome results
None listed