Japanese cedar pollinosis
Conditions
Interventions
Regular use group: Taking two puffs of Mometasone furoate hydrate nasal spray into each nostril (total 200 ug/day) every morning from the onset of nasal symptoms.
As-needed use group: Taking two puffs
Sponsors
Department of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medicine, University of Yamanashi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) A history of Japanese cedar pollinosis for at least one season before study entry. 2) Positive allergy skin test to Japanese cedar pollen or Japanese cedar pollen specific IgE RAST score >= class 2. 3) Written informed consent is required.
Exclusion criteria
Exclusion criteria: 1) Taking any immunosuppressive drugs or systemic steroid drugs within six months before study entry. 2) Taking any antibiotics within two weeks before study entry. 3) Taking any anti-allergy drugs within two weeks before study entry. 4) Using any anti-allergy nasal drops within two weeks before study entry. 5) Under treatment of buildup phase of specific immunotherapy. 6) Patients with deflected nasal septum, sinusitis, or nasal polyps which cause a barrier to evaluate nasal symptoms. 7) Patients with upper respiratory inflammation, respiratory infection, or severe bronchial asthma. 8) Patients with severe cardiac, hepatic, kidney, or hematological disease. 9) A history of hypersensitivity to mometasone furoate hydrate, loratadine, or sodium cromoglycate. 10) Pregnant or lactating women and women who may be pregnant. 11) Taking a drug of erythromycin or cimetidine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall quality of life score of Rhinoconjunctivitis Quality of Life Questionnire. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Each score of seven domains of RQLQ. 2) Two summary scores (PCS and MCS) of SF-36 v2. 3) Each severity score of four daily nasal symptoms (runny nose, itchy nose , stuffy nose, and sneezing). 4) Total nasal symptom score (the sum of four nasal symptom scores). 5) Each severity score of three daily ocular symptoms (eye itchiness, eye redness, and tearing). 6) Total ocular symptom score (the sum of three ocular symptom scores). | — |
Countries
Japan
Contacts
Public ContactGoro Takahashi
University of Yamanashi Department of Otorhinolaryngology, Head & Neck Surgery
Outcome results
None listed