Osteonecrosis of the Femoral Head
Conditions
Interventions
Period: 2 years Volume:50000000 of mesenchymal stem cell Number:1 Case number intervention: 10 cases
Sponsors
Department of Orthopedic Surgery, Kyoto University Hospital
Center for Cell and Molecular Therapy, Kyoto University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Clinical stage of Xray evaluation:Stage 3A and Stage 3B
Exclusion criteria
Exclusion criteria: Previous medical history against candidate bone Heavy smorker (Brinkman index>600) Warfarin treatment Diabetes mellitus (HbA1c>9.0%) Arteriosclerosis obliterans Pregnancy,during lactation Malignant neoplasm Cardiac infarction, brain infaction Rheumatoid arthritis Dialytic therapy Complication of blood disease Live less than 12 months Active infection Hypotension(systolic blood pressure<90mmHg) Low body weight(under 40kg) Bone marrow dysfunction (neutrophil<1500/mm3, Hb<11.0g/dL(male),Hb<10.0g/dL(women), Plt<100000/mm3) Patient with the anti-osteoporosis drug and steroid were changed within 3 months Patient which was judged as inadequate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| X-ray evaluation of clinical stage on the point of preoperation and two years after operation | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical score and bone volume on the point of preoperation, one year after operaion and two years after operation | — |
Countries
Japan
Contacts
Public ContactIzumi Hashimoto
Kyoto University Hospital Department of Orthopaedic Surgery
Outcome results
None listed