Observational Study on Cerebro- and Cardio-vascular Complication in Predialysis, Hemodialysis, and Peritoneal Dialysis Patients with Chronic Kidney Disease

Observational Study on Cerebro- and Cardio-vascular Complication in Predialysis, Hemodialysis, and Peritoneal Dialysis Patients with Chronic Kidney Disease - VCOHP Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000001589

Enrollment

300

Registered

2008-12-19

Start date

2008-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Predialysis patients with chronic kidney disease 2. Patients with end-stage renal disease on either hemodialysis or peritoneal dialysis, who started dialysis within 2 years of study entry

Exclusion criteria

Exclusion criteria: 1. Pregnant women, or women who have a possibility of pregnancy 2. Patients using acidic dialysate 3. Patients who have previously received another dialysis therapy for over 3 months 4. Patients who have previously undergone renal transplantation

Design outcomes

Secondary

Measure	Time frame
1. Incidence rate of overt cerebro- and cardio-vascular complications 2. Intima-media thickness of common carotid artery 3. Cardiac function examined by echocardiography and cine-MRI 4. Pulse wave velocity examined by MRI 5. Augmentation Index (AI) 6. Bone mineral density examined by dual-energy X-ray absorptiometry 7. Residual renal function 8. Higher brain function quantified using Japan Stroke Scale Higher Cortical Function (JSS-H) 9. Quality of life quantified using the Kidney Disease Quality of Life Short Form (KDQOL-SF)	—

Measure

Time frame

1. Incidence rate of overt cerebro- and cardio-vascular complications 2. Intima-media thickness of common carotid artery 3. Cardiac function examined by echocardiography and cine-MRI 4. Pulse wave velocity examined by MRI 5. Augmentation Index (AI) 6. Bone mineral density examined by dual-energy X-ray absorptiometry 7. Residual renal function 8. Higher brain function quantified using Japan Stroke Scale Higher Cortical Function (JSS-H) 9. Quality of life quantified using the Kidney Disease Quality of Life Short Form (KDQOL-SF)

—

Primary

Measure	Time frame
1. Alteration of brain volume in MRI 2. Alteration of calcification score in coronary CT	—

Countries

Japan

Contacts

Public ContactHisako Yoshida

Graduate School of Medical Sciences, Kyushu University Department of Integrated Therapy for Chronic Kidney Disease

hisako@kcu.med.kyushu-u.ac.jp092-642-5843

Outcome results