A randomized, double-blind, placebo- controlled, multi-center, parallel study concerning the efficacy of repetitive transcranial magnetic stimulation over the supplementary motor area in treatment of motor and non- motor symptoms in Parkinson's disease

A randomized, double-blind, placebo- controlled, multi-center, parallel study concerning the efficacy of repetitive transcranial magnetic stimulation over the supplementary motor area in treatment of motor and non- motor symptoms in Parkinson's disease - The efficacy of repetitive transcranial magnetic stimulation over the supplementary motor area in treatment of Parkinson's disease.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001576

Enrollment

150

Registered

2008-12-17

Start date

2008-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson&#39

Interventions

Repetitive transcranial magnetic stimulation over the supplementary motor area, high-frequency stimulation Repetitive transcranial magnetic stimulation over the supplementary motor area, low-frequency

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Diagnosed as Parkinson's disease (PD) according to the UK Parkinson's disease Society brain bank 2) Patients who are capable of ambulatory hospital visits 3)Patients who consented to keep drug and living conditions during the study. 4)Patients who were rated as Hoehn-Yahr grade 2 or 3 or 4. 5) Those who give us informed consent to participate in the present study after detailed explanation of the study

Exclusion criteria

Exclusion criteria: 1)The patients who underwent the TMS treatment before 2)No implantation of metal in head, except in the mouth 3) Those having heart pacemaker or drug infusion pomp 4) Serious heart disease 5)History of massive cerebral infarction, head injury, brain tumor, or epilepsy 6)Pregnant or intend to be pregnant

Design outcomes

Primary

Measure	Time frame
Unified Parkinson's Disease Rating Scale(UPDRS) part 3	—

Secondary

Measure	Time frame
UPDRS part 1,2,4, 5-point scale for daily life and tremor, Apathy scale, 17 item of Hamilton depression scale, Non-Motor Symptoms Questionnaire	—

Countries

Japan

Contacts

Public ContactHiroyuki Enomoto

Fukushima medical university Department of neurology

024-547-1248

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

A randomized, double-blind, placebo- controlled, multi-center, parallel study concerning the efficacy of repetitive transcranial magnetic stimulation over the supplementary motor area in treatment of motor and non- motor symptoms in Parkinson&#39;s disease